Professor He Xingxiang's team and Academician Wu Qingping's team from the Institute of Microbiology of the Guangdong Academy of Sciences discovered for the first time that washing bacteria transplantation has a hypotensive effect on hypertensive patients

The team of Professor He Xingxiang from the Department of Gastroenterology of the First Affiliated Hospital of Guangdong Pharmaceutical University and the team of Academician Wu Qingping from the Institute of Microbiology, Guangdong Academy of Sciences discovered for the first time that washed microbiota transplantation (WMT) can effectively reduce the blood pressure of hypertensive patients, and the relevant research results were published In Frontiers in Cellular and Infection Microbiology ( JCR1 area) international professional journal.

Hypertension is a common chronic disease in clinic. According to statistics, there are more than 1 billion hypertensive patients in the world, and more than 300 million hypertensive patients in China . Hypertension is the most important independent risk factor among many risk factors for cardiovascular and cerebrovascular diseases, and it is also the main cause of death from cardiovascular and cerebrovascular diseases in my country. The pathogenesis of essential hypertension is very complicated. Studies have shown that many factors such as environment and genetics are involved in the occurrence and development of hypertension. Recently, a large number of clinical studies have found that intestinal flora may be related to hypertension, which is manifested by the dysbiosis of intestinal flora in patients with hypertension (the abundance of probiotics in the intestine decreases and the abundance of pathogenic bacteria increases). In addition, animal experiments have found that transplanting the intestinal flora of normotensive rats into hypertensive rats can significantly reduce the blood pressure of hypertensive rats. However, whether WMT has an antihypertensive effect on hypertensive patients is still unclear.

In order to understand the curative effect of WMT on patients with hypertension, the team of Professor He Xingxiang and Academician Wu Qingping made a statistical analysis of patients who received WMT and had follow-up in the First Affiliated Hospital of Guangdong Pharmaceutical University from January 1 , 2017 to August 31 , 2020 . Inpatient data. Finally, 260 patients were included , including 73 hypertensive patients and 187 normotensive patients.

The results showed that WMT can significantly improve the blood pressure of patients with hypertension: after the first course of WMT , the blood pressure of patients with hypertensionBoth systolic and diastolic blood pressures were significantly improved; systolic blood pressure was also significantly improved in hypertensive patients after the second course of WMT (Fig. 1A ). Meanwhile, WMT had no significant effect on blood pressure values ​​in normotensive patients (Fig. 1B ).

Figure 1 Effect of WMT on blood pressure in hypertensive patients and normotensive patients

We further analyzed which characteristics of hypertensive patients have better antihypertensive effect of WMT . It was found that the antihypertensive effect of hypertensive patients undergoing WMT due to organic diseases (such as inflammatory bowel disease, chronic liver disease, and gastroesophageal reflux disease) was significantly better than that of patients with functional diseases (such as functional bowel disease, functional Dyspepsia and intestinal dysbiosis) in hypertensive patients undergoing WMT (Fig. 2A ). At the same time, hypertensive patients who did not take antihypertensive drugs (Figure 2B ) and hypertensive patients who underwent WMT through lower gastrointestinal catheterization (Figure 2D ) had better antihypertensive efficacy. However, there was no significant difference in the blood pressure-lowering effect of WMT between patients with and without hypertensive complications (Fig. 2C ).

Figure 2 The effect of WMT on blood pressure in patients with hypertension with different characteristics

This study found that the incidence of adverse reactions in patients receiving WMT was only 3.07% , mainly mild adverse reactions such as abdominal pain, abdominal distension, and diarrhea, and no serious adverse reactions were seen in all patients.

Finally, gut microbial profiles were also analyzed in hypertensive patients before and after WMT (Fig . 3 ). After WMT , 6 of 8 hypertensive patients had increased gut microbial diversity (Figure 4A ), and the gut microbes of hypertensive patients after WMT treatment were closer to those of healthy donors (Figure 4B ).

Figure 3 The characteristics of intestinal flora of WMT donors and patients with hypertension

Figure 4 The effect of WMT on the intestinal flora of patients with hypertension

  In conclusion, the results of this study suggest that correction of intestinal microecological disturbance by WMT may be a safe and effective method for the treatment of hypertension.

Attachment: original text

Attachment download: Washed Microbiota Transplantation Lowers Blood Pressure in Patients With Hypertension.pdf