Associate Researcher Lu Xuemei's team from the School of Life Science and Biopharmaceuticals of our school has made new progress in targeted drug delivery research
Recently, with the School of Life Science and Biopharmaceuticals of Guangdong Pharmaceutical University as the first signing unit, and Associate Researcher Lu Xuemei as the corresponding author, the research results were published in the TOP journal "Theranostics" of the Chinese Academy of Sciences ( IF : 8.579 ) ."Colon tissue-aaccumulating mesoporous carbonnanoparticles loaded withMusca domestica cecropin for ulcerative colitistherapy " , reportsAn orally-loaded antimicrobial peptide Cecropin ( Musca domestica Cecropin, MDC ) mesoporous carbon nanoparticle ( Mesoporous Carbon Nanoparticles, MCNs ) drug delivery system with colonic aggregation provides a new strategy for the precise treatment of ulcerative colitis .
In recent years, the incidence of ulcerative colitis ( Ulcerative Colitis, UC ) has increased significantly. Its inflammatory response relieves symptoms, but the above-mentioned drugs have poor long-term curative effect and relatively large side effects. Therefore, drug research for ulcerative colitis is of great significance. Housefly Cecropin is an insect antimicrobial peptide containing 40 amino acids. The research team's previous research found that it has antibacterial, anti-inflammatory activities and colonic mucosal protection. Mesoporous carbon has the characteristics of large pore volume and high specific surface area, easy surface targeted modification, high drug loading rate, and good stability, and has shown great potential in drug delivery systems . In this study, the researchers used a one-step soft template method to synthesize mesoporous carbon nanospheres with a particle size of about 120 nm , and loaded the antimicrobial peptide MDC to prepare a new oral nano drug delivery system MDC@MCNs . In the mouse toxicology evaluation experiment and cytotoxicity evaluation experiment, MDC@MCNs showed good biocompatibility. The results of animal experiments show that after oral administration of MDC@MCNs delivered to the colon, more adhesions and aggregations can be made to the affected area, prolonging its colonic retention, increasing oral bioavailability, and exerting anti-inflammatory, anti-oxidative stress, regulating immunity and intestinal tract in the release of MDC . While disturbing the flora, it can also significantly improve the damage of the tight junction structure of colonic epithelial cells, and realize the efficient delivery of MDC to UC diseased tissues, thereby enhancing its therapeutic effect on ulcerative colitis.
MDC@MCNs new oral nano drug delivery system
references:
Zhang L, Gui S, Xu Y, Zeng J, Wang J, Chen Q, Su L, Wang Z, Deng R, Chu F, Liu W, Jin X, Lu X. Colon tissue-accumulating mesoporous carbon nanoparticles loaded with Musca domestica cecropin for ulcerative colitis therapy. Theranostics 2021; 11(7):3417-3438. doi:10.7150/thno.53105.
